At least 1 death was documented in the nursing infant who was exposed to large levels of morphine in breast milk because the mother was an extremely-rapid metabolizer of codeine. Breastfeeding is not recommended throughout treatment with acetaminophen and codeine phosphate tablets.
Embryo-Fetal Toxicity Inform female patients of reproductive potential that acetaminophen and codeine phosphate tablets can cause fetal damage and to tell the prescriber of the identified or suspected pregnancy (see Safety measures, Pregnancy).
Notice that this record is not really all-inclusive and consists of only widespread medications which will interact with codeine. You should confer with the prescribing information and facts for codeine for a complete listing of interactions.
DHC seems to be a lot less sedating than codeine and it definately overpowers it once you use The 2 together. Combining this cough syrup with CWE is quite nauseating likewise I really should increase, along with the sorbitol material gives several the runs.
Regularly Examine patients, specially when initiating and titrating acetaminophen and codeine phosphate tablets and when acetaminophen and codeine phosphate tablets are given concomitantly with other drugs that depress respiration (see WARNINGS). Alternatively, consider the usage of non-opioid analgesics in these patients.
I constantly dosed it with the codeine and by no means noticed any true loss in effects, click here probably because of how I metabolize codeine or because of the effects in the promethazine balancing out the inhibition and after that some.
Codeine sulfate was not mutagenic during the in vitro bacterial reverse mutation assay or clastogenic from the in vitro Chinese hamster ovary mobile chromosome aberration assay.
Antihistamines- Antihistamines are really useful in the potentiation of codeine and other opiates, not only do sure antihistamines enhance sedation but they help to counteract some unfavorable effects on the opiate like itching and nausea.
If concomitant use with a CYP2D6 inhibitor is critical, or if a CYP2D6 inhibitor is discontinued soon after concomitant use, consider dosage adjustment of acetaminophen and codeine phosphate tablets and Examine patients closely at Regular intervals.
Dependence Both equally tolerance and Actual physical dependence can create for the duration of Serious opioid therapy. Tolerance is a physiological state characterized by a diminished reaction to the drug after repeated administration (i.
There aren't any typical opioid tapering schedules that are ideal for all patients. Good medical observe dictates a patient-certain plan to taper the dose on the opioid step by step. For patients on acetaminophen and codeine phosphate tablets who are physically opioid-dependent, initiate the taper by a small ample increment (e.
If concomitant use is warranted, Appraise patients for indications of urinary retention or decreased gastric motility when acetaminophen and codeine phosphate tablets are used concomitantly with anticholinergic drugs.
You should not use codeine in case you have extreme breathing problems, a blockage in your stomach or intestines, or Repeated asthma attacks or hyperventilation.
The excessive intake of acetaminophen may very well be intentional to cause self-damage or unintentional as patients attempt to attain far more pain relief or unknowingly take other acetaminophen-containing products and solutions.